幹細胞具有再生能力和多向分化潛力，對疾病治療和基本醫學研究，舉足輕重。 尿源性幹細胞（USC）是新發現的幹細胞類型，其生物學特徵類似間充質幹細胞（MSC），包括雙倍時間及免疫表型。尿源性幹細胞無創，易於從自解尿中獲得，穩定培養。基於此領域的進展，尿源性幹細胞及其分泌物是幹細胞越來越理想的來源。尿源性幹細胞可調節細胞免疫系統、氧化應激、血運重建、細胞凋亡和組織自噬。這篇綜述總結尿源性幹細胞在組織再生和各種疾病治療的應用。 此外，我們分析其局限後，預計醫學界會發展出更可行的治療策略，促進尿源性幹細胞為本的個性化治療。
原文作者：Zhou Q, Cheng Y, Sun F, Shen J, Nasser MI, Zhu P, Zhang X, Li Y, Yin G, Wang Y, Wu X, Zhao M. A Comprehensive Review of the Therapeutic Value of Urine-Derived Stem Cells. Front Genet. 2022 Jan 3;12:781597. doi: 10.3389/fgene.2021.781597. PMID: 35047009; PMCID: PMC8762167.
Stem cells possess regenerative powers and multidirectional differentiation potential and play an important role in disease treatment and basic medical research. Urine-derived stem cells (USCs) represent a newly discovered type of stem cell with biological characteristics similar to those of mesenchymal stromal cells (MSCs), including their doubling time and immunophenotype. USCs are noninvasive and can be readily obtained from voided urine and steadily cultured. Based on advances in this field, USCs and their secretions have increasingly emerged as ideal sources. USCs may play regulatory roles in the cellular immune system, oxidative stress, revascularization, apoptosis and autophagy. This review summarizes the applications of USCs in tissue regeneration and various disease treatments. Furthermore, by analysing their limitations, we anticipate the development of more feasible therapeutic strategies to promote USC-based individualized treatment.
Article link: https://www.hongkongurinetherapy.com/%e5%85%a8%e9%9d%a2%e7%b6%9c%e8%bf%b0%e5%b0%bf%e6%ba%90%e6%80%a7%e5%b9%b9%e7%b4%b0%e8%83%9e%e7%9a%84%e6%b2%bb%e7%99%82%e5%83%b9%e5%80%bc%ef%bc%88%e5%9c%8b%e9%9a%9b%e6%ac%8a%e5%a8%81%e9%86%ab%e5%ad%b8/
來源 (Source): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762167/
Keywords: urine-derived stem cells, multiple differentiation, molecular mechanisms, disease treatment, drug discovery, tissue engineering